A Case of Podocytic Infolding Glomerulopathy with Focal Segmental Glomerulosclerosis
نویسندگان
چکیده
Podocytic infolding glomerulopathy (PIG) has been proposed as a new disease entity. A 14-year-old girl underwent renal biopsy at our institution because of a chance finding of proteinuria. Light microscopic findings revealed a minor glomerular abnormality, but under a higher magnification, after periodic acid methenamine silver staining, a bubbling appearance in the glomerular basement membrane (GBM) was observed. An electron microscopic examination revealed microspheres in the GBM, which were sparse but global. The patient was diagnosed as having PIG. After 3 years, her urinary protein had increased and a second biopsy was performed, showing focal segmental glomerulosclerosis in addition to a lesser degree of podocytic infolding than at the first biopsy. This is the first report of a case complicated by a different type of glomerulonephritis after being diagnosed as PIG. A few cases of PIG are complicated by focal segmental glomerulosclerosis, suggesting several mechanisms for the disorder.
منابع مشابه
Collapsing glomerulopathy in sickle cell disease: a case report
INTRODUCTION Sickle cell disease has been associated with many renal structural and functional abnormalities. Collapsing glomerulopathy or the collapsing variant of focal segmental glomerulosclerosis is a rare clinicopathologic entity in patients with sickle cell disease that requires timely diagnosis and aggressive management. CASE PRESENTATION In this case report we describe a 21-year-old A...
متن کاملExceptional Case Cytomegalovirus-induced collapsing focal segmental glomerulosclerosis
Collapsing glomerulopathy is an aggressive morphologic variant of focal segmental glomerulosclerosis which typically presents with nephrotic syndrome and rapidly progressive renal failure. Most cases of collapsing glomerulopathy are associated with human immunodeficiency virus infection. We present a rare case of collapsing glomerulopathy associated with acute cytomegalovirus (CMV) infection in...
متن کاملCytomegalovirus-induced collapsing focal segmental glomerulosclerosis
Collapsing glomerulopathy is an aggressive morphologic variant of focal segmental glomerulosclerosis which typically presents with nephrotic syndrome and rapidly progressive renal failure. Most cases of collapsing glomerulopathy are associated with human immunodeficiency virus infection. We present a rare case of collapsing glomerulopathy associated with acute cytomegalovirus (CMV) infection in...
متن کاملA case of podocytic infolding glomerulopathy with multiple myeloma
BACKGROUND Podocytic infolding glomerulopathy (PIG) is a recently described condition causing rare pathological changes to the glomeruli, and has attracted considerable attention. PIG is characterized by specific changes to the thickened glomerular basement membrane (GBM), including microspheres, microtubular structures, and podocytic infolding. Only a small number of cases of PIG have been rep...
متن کاملPodocytic Infolding Glomerulopathy: Pathological Entity or a Distinct Disease Process
We describe a 32-year-old pregnant female with a very distinctive glomerular morphology. She presented with increasing proteinuria in her third trimester and carried a pre-existing diagnosis of systemic lupus erythematosus (SLE). Renal biopsy showed diffusely thickened capillary loops suggestive of class V membranous lupus nephritis. However the immunofluorescence was negative and on electron m...
متن کامل